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3 Ways an Oxaloacetate Supplement Can Protect You

An oxaloacetate supplement provides powerful protection against the effects of cancer, stroke, and traumatic brain injury.

Oxaloacetate Supplement 3 Ways an Oxaloacetate Supplement Can Protect YouOxaloacetate is an obscure molecule that plays a role in energy production. Researchers have learned that it can also remove excess glutamate from the bloodstream. Glutamate can cause extensive brain damage in the event of a stroke or concussion, and it is a preferred fuel for many different types of cancer cells. Oxaloacetate’s removal of glutamate has a protective effect against these hazards.

Oxaloacetate increases energy production

Cells can produce energy in two different ways. The more primitive, less effective method is glycolysis. The more advanced and efficient method is oxidative phosphorylation. This occurs in the mitochondria, and it produces eight times more energy than glycolysis—while using the same amount of fuel.[1] Oxaloacetate is an important part of the metabolic cycle that allows oxidative phosphorylation to occur. Without this molecule, cells are forced to rely more heavily on glycolysis.[2] This can lead to decreased production of energy and a decreased supply of blood sugar. In fact, studies indicate that a lack of oxaloacetate can cause energy production to fall by nearly 500%.[3]

Oxaloacetate starves cancer

Cancerous cells rely on simple sugars and glutamate for their fuel supply, and this is especially true for brain tumors.[4] Glutamate also allows cancer cells to grow and divide.[5] When simple sugars and glutamate are abundant, cancer cells can produce more energy. This makes them more capable of spreading and more resistant to treatment. Fortunately, studies have shown that the consumption of an oxaloacetate supplement can decrease blood glutamate levels by 40%.[6,7] This leads to a reduction of tumor size and invasiveness.[8] Furthermore, patients who are given an oxaloacetate supplement experience an increased survival rate of 237%.[8]

Oxaloacetate reduces brain trauma

In addition to its use as a cancer fuel, glutamate can also trigger the excitation of neurons.[9] This is especially dangerous to stroke victims, and over time, it causes damage to brain cells. However, as oxaloacetate removes glutamate from the bloodstream, glutamate in the brain and spinal fluid is forced to exit, as well.[10] This allows the brain to recover from strokes and traumatic injuries.[10] Without glutamate, neurons can naturally restore their long-term potentiation, allowing the cells to transmit signals more quickly, which leads to faster neural communication and improved brain function.

How to find an oxaloacetate supplement

Because oxaloacetate is a cellular metabolite, there is no effective way to obtain it from dietary sources. It must be refined and used as a supplement, and is available in capsule form.  As a natural part of the body’s cellular processes, oxaloacetate is a safe supplement with no side effects. Read about another glutamate-fighting supplement, N-acetyl cysteine here.

Share your experience

Have you tried an oxaloacetate supplement? Share your experience with the readers of Natural Health Advisory by commenting below.


[1] The Cell: A Molecular Approach. 2nd edition.

[2] Biochemistry. 5th edition.

[3] J Neurochem. 1988 Mar;50(3):673-80.

[4] Invest New Drugs. 2012 Feb 2.

[5] Trends Biochem Sci. Aug 2012; 35(8): 427-433.

[6] Exp Neurol. 2007 Jan;203(1):213-20.

[7] Neurotherapeutics. July 2012; 9(3): 649-657.

[8] Invest New Drugs. 2012 Feb 2.

[9] Stroke. 1996 Jun;27(6):1060-5.

[10] Eur J Pharmacol. 2009 Feb 14;604(1-3):51-7.

Posted in Natural Health 101.

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7 Responses

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  1. Gloria says

    The article about oxaloacetate was good but vague in telling how much to take and the best way to take it.

  2. Jeff Riddle says

    I’m glad that you mentioned that. The studies listed used 1 dose of about 3.5mg of oxaloacetate (when converted to a human dose), and glutamate reducing affects were seen after 1-2 days.

    Oxaloacetate is a small piece of a complicated biological pathway, so it’s overlooked and not well known as a supplement; making it difficult to find. I would look for it in capsule form, or ask a naturopathic doctor. I first learned about it at a conference with some doctors who were using it as a chemotherapeutic agent.

    In the case of brain cancer or stroke, I think it is a very important tool to consider.

  3. Max says

    Where is it available, except for Bulletproof?

  4. Jeff Riddle says

    Thanks for asking. To be honest, it’s a pretty obscure supplement right now, which is a good thing because that tells you it isn’t a gimmick that someone’s trying to profit from. I’ll ask some ND herbalists if they know a good source, and then post back here in the comments in a couple of days.

  5. Jeff Riddle says

    Try searching for it as Oxaloacetic acid. It’s the same thing, just a different chemical name. I was able to find a few different options that way.

  6. lorreann says

    I read somewhere in one of these articles that Benedene has the patent on it in a certain heated form. That may be why we can’t find it other places (except Bulletproof). Here’s the link to Benedene but I’ve had good luck with other Bulletproof products and trust the company so I will stick with them unless it get’s cheaper somewhere else. http://www.benagene.com

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